PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus

نویسندگان

  • Wei Wang
  • Zhigang Song
  • Wencai Guan
  • Yi Liu
  • Xiaonan Zhang
  • Lei Xu
  • Jianhua Li
  • Zhenghong Yuan
  • Yunwen Hu
چکیده

Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment. We developed a real-time reverse transcription PCR and single nucleotide polymorphism probes to differentiate this mutant strain in mixed virus populations in human specimens.

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عنوان ژورنال:

دوره 20  شماره 

صفحات  -

تاریخ انتشار 2014